Pluripotent stem cells show a remarkable ability to self-organize and differentiate in vitro in
three-dimensional aggregates, known as organoids or organ spheroids, and to recapitulate …

Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …

To model human neural-cell-fate specification and to provide cells for regenerative
therapies, we have developed a method to generate human neural progenitors and neurons …

For the promise of human induced pluripotent stem cells (iPSCs) to be realized, it is
necessary to ask if and how efficiently they may be differentiated to functional cells of various …

Monogenic neurodevelopmental disorders provide key insights into the pathogenesis of
disease and help us understand how specific genes control the development of the human …

Human pluripotent stem cells have the potential to provide comprehensive model systems
for the earliest stages of human ontogenesis. To serve in this capacity, these cells must …

Progress in elucidating the molecular and cellular pathophysiology of neuropsychiatric
disorders has been hindered by the limited availability of living human brain tissue. The …

Human pluripotent stem cells (hPSCs) have been differentiated efficiently to neuronal cell
types. However, directed differentiation of hPSCs to astrocytes and astroglial subtypes …

Neural stem cells (NSCs) yield both neuronal and glial progeny, but their differentiation
potential toward multiple region-specific neuron types remains remarkably poor. In contrast …

The transcriptional regulation of neuroectoderm (NE) specification is unknown. Here we
show that Pax6 is uniformly expressed in early NE cells of human fetuses and those …