Biological importance of structurally diversified chromenes
Compounds incorporating the chromene scaffold are largely present in natural products and
display a wide variety of biological activities. Their low toxicity combined to the broad …
display a wide variety of biological activities. Their low toxicity combined to the broad …
CB2: a cannabinoid receptor with an identity crisis
CB2 was first considered to be the 'peripheral cannabinoid receptor'. This title was bestowed
based on its abundant expression in the immune system and presumed absence from the …
based on its abundant expression in the immune system and presumed absence from the …
Chronic cannabinoid receptor 2 activation reverses paclitaxel neuropathy without tolerance or cannabinoid receptor 1–dependent withdrawal
L Deng, J Guindon, BL Cornett, A Makriyannis… - Biological …, 2015 - Elsevier
Background Mixed cannabinoid receptor 1 and 2 (CB 1 and CB 2) agonists such as Δ 9-
tetrahydrocannabinol (Δ 9-THC) can produce tolerance, physical withdrawal, and unwanted …
tetrahydrocannabinol (Δ 9-THC) can produce tolerance, physical withdrawal, and unwanted …
Ruthenium(II)-Catalyzed Regioselective C–H Arylation of Cyclic and N,N-Dialkyl Benzamides with Boronic Acids by Weak Coordination
We disclose a general method for selective ortho-C–H arylation of cyclic and N, N-dialkyl
benzamides with boronic acids enabled by versatile ruthenium (II) complexes. This method …
benzamides with boronic acids enabled by versatile ruthenium (II) complexes. This method …
Intrathecal cannabilactone CB2R agonist, AM1710, controls pathological pain and restores basal cytokine levels
JL Wilkerson, KR Gentry, EC Dengler, JA Wallace… - PAIN®, 2012 - Elsevier
Spinal glial and proinflammatory cytokine actions are strongly implicated in pathological
pain. Spinal administration of the anti-inflammatory cytokine interleukin (IL)-10 abolishes …
pain. Spinal administration of the anti-inflammatory cytokine interleukin (IL)-10 abolishes …
[HTML][HTML] The role of cannabinoid signaling in acute and chronic kidney diseases
F Barutta, G Bruno, R Mastrocola, S Bellini, G Gruden - Kidney international, 2018 - Elsevier
The endogenous cannabinoids anandamide and 2-arachidonoylglycerol bind to the
cannabinoid receptors of type 1 and 2. These receptors are also the binding sites for …
cannabinoid receptors of type 1 and 2. These receptors are also the binding sites for …
Cannabinoid CB2 receptor orthologues; in vitro function and perspectives for preclinical to clinical translation
ER Carruthers, NL Grimsey - British Journal of Pharmacology, 2024 - Wiley Online Library
Cannabinoid CB2 receptor agonists are in development as therapeutic agents, including for
immune modulation and pain relief. Despite promising results in rodent preclinical studies …
immune modulation and pain relief. Despite promising results in rodent preclinical studies …
The Maintenance of Cisplatin- and Paclitaxel-Induced Mechanical and Cold Allodynia is Suppressed by Cannabinoid CB2 Receptor Activation and Independent of …
Background: Chemotherapeutic agents produce dose-limiting peripheral neuropathy
through mechanisms that remain poorly understood. We previously showed that AM1710, a …
through mechanisms that remain poorly understood. We previously showed that AM1710, a …
Latest advances in cannabinoid receptor agonists
GA Thakur, R Tichkule, S Bajaj… - Expert opinion on …, 2009 - Taylor & Francis
Background: Since the discovery of cannabinoid receptors and their endogenous ligands in
early 1990s, the endocannabinoid system has been shown to play a vital role in several …
early 1990s, the endocannabinoid system has been shown to play a vital role in several …
Metabolites of cannabigerol generated by human cytochrome P450s are bioactive
The phytocannabinoid cannabigerol (CBG) is the central biosynthetic precursor to many
cannabinoids, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Though the …
cannabinoids, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Though the …