Organophosphonic acids are unique as natural products in terms of stability and mimicry.
The C–P bond that defines these compounds resists hydrolytic cleavage, while the …

The idea of “reasonableness” of organic reactions is based on recorded evidence of
reaction patterns. The logical patterns are organized based on structural and functional …

The underlying molecular mechanisms of cooperativity and allosteric regulation are well
understood for many proteins, with haemoglobin and aspartate transcarbamoylase serving …

Bringing a knowledge of enzymology into research in vivo and in situ is of great importance
in understanding systems biology and metabolic regulation. The central metabolic …

Mechanism-based inhibitors and both forward and reverse genetics have proved to be
essential tools in revealing roles for specific enzymatic processes in cellular function. Here …

The bacterial metabolic enzyme 1-deoxy-d-xylulose-5-phosphate synthase (DXPS)
catalyzes the thiamin diphosphate (ThDP)-dependent formation of DXP from pyruvate and d …

Enzymes that use the cofactor thiamin diphosphate (ThDP, 1), the biologically active form of
vitamin B1, are involved in numerous metabolic pathways in all organisms. Although a …

New antimicrobial strategies are needed to address pathogen resistance to currently used
antibiotics. Bacterial central metabolism is a promising target space for the development of …

Emerging resistance of human pathogens to anti-infective agents make it necessary to
develop new agents to treat infection. The methylerythritol phosphate pathway has been …

Carbenes are highly reactive chemical compounds that are exploited as ligands in
organometallic chemistry and are powerful organic catalysts. They were postulated to occur …