Liver disease, involving a wide range of liver pathologies from fatty liver, hepatitis, and
fibrosis to cirrhosis and hepatocellular carcinoma, is a serious health problem worldwide. In …

Privileged structures are conductive to discover novel bioactive substances because they
can bind to multiple targets with high affinity. Quinones are considered to be a privileged …

Background: Hypericin is a prominent secondary metabolite mainly existing in genus
Hypericum. It has become a research focus for a quiet long time owing to its extensively …

Novel duck reovirus (NDRV) disease is a serious infectious disease for poultry, for which no
effective therapy has been established. Therefore, development of novel antivirals against …

Viruses spread rapidly and are well-adapted to changing environmental events. They can
infect the human body readily and trigger fatal diseases. A limited number of drugs are …

Background Adult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell
leukemia virus type 1 (HTLV-1). ATL carries a poor prognosis due to chemotherapy …

Bunyaviruses are significant human pathogens, causing diseases ranging from hemorrhagic
fevers to encephalitis. Among these viruses, La Crosse virus (LACV), a member of the …

Anthraquinones (AQs) are secondary metabolites widely distributed in nature. Interesting
applications of plant extracts containing AQs include the treatment of Hepatitis C and cancer …

Abstract Background Hepatitis C virus (HCV) is a globally prevalent pathogen and a leading
cause of death and morbidity. Traditional therapy with pegylated interferon-and ribavirin has …

Ethnopharmacological relevance Hypericum perforatum L. has a long history in many
countries of being used as a herbal medicine. It is also widely used in Chinese herbal …