Optogenetic probes for measuring membrane potential

AE Cohen, D Hochbaum, P Zou, SL Farhi… - US Patent …, 2016 - Google Patents
2015-07-02 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Optogenetic probes for measuring membrane potential

AE Cohen, J Kralj, AD Douglass - US Patent 9,791,455, 2017 - Google Patents
2015-07-01 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Optical selection of cells

AE Cohen, MP Chien - US Patent 10,077,463, 2018 - Google Patents
5, 925, 523 A 7/1999 Dove et al. 6, 107, 066 A 8/2000 Tsien et al. 6, 200, 759 B1 3/2001
Dove et al. 6, 243, 197 B1 6/2001 Schalz 6, 885, 492 B2 4/2005 DeSimone et al. 6, 898, 004 …

Optogenetic probes for measuring membrane potential

AE Cohen, D Hochbaum, P Zou, SL Farhi… - US Patent …, 2019 - Google Patents
Provided herein are variants of an archaerhodopsin useful for application such as optical
measurement of membrane potential. The present invention also relates to polynucleotides …

Systems, methods, and workflows for optogenetics analysis

AE Cohen, J Kralj, AD Douglass… - US Patent 10,161,937, 2018 - Google Patents
The invention provides methods for characterizing cellular physiology by incorporating into
an electrically excitable cell an optical reporter of, and an optical actuator of, electrical …

Optogenetic probes for measuring membrane potential

AE Cohen, J Kralj, AD Douglass - US Patent 10,352,945, 2019 - Google Patents
2018-02-21 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

Optogenetic probes for measuring membrane potential

AE Cohen, D Hochbaum, P Zou, SL Farhi… - US Patent …, 2020 - Google Patents
Provided herein are variants of an archaerhodopsin useful for application such as optical
measurement of membrane potential. The present invention also relates to polynucleotides …

Pattern change discovery between high dimensional data sets

Y Xu, ZM Zhang - US Patent 11,947,622, 2024 - Google Patents
The general problem of pattern change discovery between high-dimensional data sets is
addressed by considering the notion of the principal angles between the subspaces is …

Diagnostic methods for neural disorders

KC Eggan, A Cohen, J Kralj, E Kiskinis - US Patent 10,613,079, 2020 - Google Patents
The invention generally relates to optical methods for the diagnosis of neuronal condition by
converting a cell from a patient into a neuron and optically evaluating action poten-tials of …

Automated system for high-throughput all-optical dynamic electrophysiology

E Entcheva, A Klimas - US Patent 11,680,904, 2023 - Google Patents
G01N33/5008—Chemical analysis of biological material, eg blood, urine; Testing involving
biospecific ligand binding methods; Immunological testing involving human or animal cells …