Mammalian histone demethylases of the KDM5 family are mediators of gene expression
dynamics during developmental, cellular differentiation, and other nuclear processes. They …

Gene expression is influenced at many layers by a fine-tuned crosstalk between multiple
extrinsic signalling pathways and intrinsic regulatory molecules that respond to …

Abstract Polycomb (PcG) and Trithorax (TrxG) group proteins give stable epigenetic memory
of silent and active gene expression states, but also allow poised states in pluripotent cells …

Numerous genes are associated with neurodevelopmental disorders such as intellectual
disability and autism spectrum disorder (ASD), but their dysfunction is often poorly …

The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated
CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although …

Mutations in KDM5 family histone demethylases cause intellectual disability in humans.
However, the molecular mechanisms linking KDM5-regulated transcription and cognition …

The attachment of one or more ubiquitin molecules by SCF (S kp–C ullin–F-box) complexes
to protein substrates targets them for subsequent degradation by the 26S proteasome …

The transcriptional co-regulator SIN3 influences gene expression through multiple
interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are …

Mechanisms that regulate tissue-specific progenitors for maintenance and differentiation
during development are poorly understood. Here, we demonstrate that the co-repressor …

Mutations in the lysine demethylase 5 (KDM5) family of transcriptional regulators are
associated with intellectual disability, yet little is known regarding their spatiotemporal …