R Kirtana, S Manna, SK Patra - Experimental Cell Research, 2020 - Elsevier
Gene expression is influenced at many layers by a fine-tuned crosstalk between multiple extrinsic signalling pathways and intrinsic regulatory molecules that respond to …
Abstract Polycomb (PcG) and Trithorax (TrxG) group proteins give stable epigenetic memory of silent and active gene expression states, but also allow poised states in pluripotent cells …
Numerous genes are associated with neurodevelopmental disorders such as intellectual disability and autism spectrum disorder (ASD), but their dysfunction is often poorly …
F Beurton, P Stempor, M Caron, A Appert… - Nucleic Acids …, 2019 - academic.oup.com
The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although …
Mutations in KDM5 family histone demethylases cause intellectual disability in humans. However, the molecular mechanisms linking KDM5-regulated transcription and cognition …
LJ de Assis, M Ulas, LNA Ries, NAM El Ramli… - MBio, 2018 - Am Soc Microbiol
The attachment of one or more ubiquitin molecules by SCF (S kp–C ullin–F-box) complexes to protein substrates targets them for subsequent degradation by the 26S proteasome …
VJ Robert, M Caron, L Gely, A Adrait… - …, 2023 - journals.biologists.com
The transcriptional co-regulator SIN3 influences gene expression through multiple interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are …
Mechanisms that regulate tissue-specific progenitors for maintenance and differentiation during development are poorly understood. Here, we demonstrate that the co-repressor …
Mutations in the lysine demethylase 5 (KDM5) family of transcriptional regulators are associated with intellectual disability, yet little is known regarding their spatiotemporal …