Importance of the field: Targeted liposomal drugs represent the next evolution of liposomal
drug delivery in cancer treatment. In various preclinical cancer models, antibody-targeted …

Protein stability is not just an academic matter. Biotechnology, Cell Biology and Drug Design
are some of the fields where both theoretical and practical knowledge of protein stability is …

The 185 kDa transmembrane glycoprotein human epidermal growth factor receptor 2 (HER-
2)(p185/neu, c-ErbB-2) is overexpressed in breast and ovarian cancers. Overexpression in …

Single domain antibodies (sdAb) that bind ricin with high affinity and specificity were
selected from a phage display library derived from the mRNA of heavy chain antibodies …

The interdomain instability of single-chain fragment variable (scFv) might result in
intermolecular aggregation and loss of function. In the present study, we stabilized H4—an …

Protein intermediates in equilibrium with native states may play important roles in protein
dynamics but, in cases, can initiate harmful aggregation events. Investigating equilibrium …

Aβ (amyloid β) immunotherapy has been revealed as a possible tool in Alzheimer's disease
treatment. In contrast with complete antibodies, the administration of scFvs (single-chain …

During storage stability studies of a monoclonal antibody (mAb) it was determined that the
primary route of degradation involved fragmentation into lower molecular weight species …

Increasing the thermostability of proteins is often crucial for their successful use as analytic,
synthetic or therapeutic tools. Most rational thermostabilization strategies were developed …

The vast majority of our knowledge on protein stability arises from the study of simple two-
state models. However, proteins displaying equilibrium intermediates under certain …