Nicotinic acetylcholine, serotonin type 3, γ-amminobutyric acid type A, and glycine receptors
are major players of human neuronal communication. They belong to the family of …

It is over forty years since the major neurotransmitters and their protein receptors were
identified, and over twenty years since determination of the first amino-acid sequences of the …

The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and
in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a …

Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter
GABA (γ-aminobutyric acid) and its synaptic target, the type A GABA receptor (GABAA …

Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid
inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers …

Fast chemical communication in the nervous system is mediated by neurotransmitter-gated
ion channels. The prototypical member of this class of cell surface receptors is the cation …

Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast
neurotransmission throughout the nervous system. The molecular processes of …

Piezo1 and Piezo2 encode mechanically activated cation channels that function as
mechanotransducers involved in vascular system development and touch sensing …

The nicotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the
free energy of binding of the neurotransmitter acetylcholine into opening of its central pore …

Pentameric ligand‐gated ion channels (pLGICs) mediate fast neurotransmission in the
nervous system. Their dysfunction is associated with psychiatric, neurological and …