The heat shock protein 90 (Hsp90) family consists of four highly conserved isoforms: the
mitochondrial TRAP-1, the endoplasmic reticulum-localised Grp94, and the cytoplasmic …

Constitutively activated rat sarcoma (RAS) GTPases are one of the major drivers of tumor
growth and are difficult drug targets. The glucocorticoid receptor (GR), a nuclear receptor …

Clinical hyperthermic intraperitoneal chemotherapy (HIPEC) is regarded as a potential
treatment that can prolong survival of patients with peritoneal metastases after cytoreductive …

Triple-negative breast cancer (TNBC) remains a treatment challenge and requires
innovative therapies. Hsp90, crucial for the stability of numerous oncogenic proteins, has …

HSP90 has emerged as an appealing anti-cancer target. However, HSP90 inhibitors
(HSP90i) are characterized by limited clinical utility, primarily due to the resistance …

A pharmacophore-hybridized strategy based on previously reported HSP90 C-terminal
inhibitors was utilized to prepare 32 aryl/penta-1, 4-dien-3-one/amine hybrids. Among them …

Phototherapies induced by photoactive nanomaterials have inspired and accentuated the
importance of nanomedicine in cancer therapy in recent years. During these light-activated …

Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing
protein structures, facilitating the repair or degradation of damaged proteins, and …

The heat shock factor 1 (HSF1) is a transcription factor that itself is a sensor for stress and
integrates various intrinsic or environmental stress sensing pathways. Thus HSF1 …

As a molecular chaperone, heat shock protein 90 (HSP90) plays important roles in the
folding, stabilization, activation, and degradation of over 500 client proteins, and is …