ADAR1-mediated RNA editing and its role in cancer
It is well known that the stability of RNA, the interaction between RNA and protein, and the
correct translation of protein are significant forces that drive the transition from normal cell to …
correct translation of protein are significant forces that drive the transition from normal cell to …
[HTML][HTML] The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression
Abstract The Anaphase Promoting Complex (APC), a multi-subunit ubiquitin ligase,
facilitates mitotic and G1 progression, and is now recognized to play a role in maintaining …
facilitates mitotic and G1 progression, and is now recognized to play a role in maintaining …
hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1
The structure of messenger RNA is important for post-transcriptional regulation, mainly
because it affects binding of trans-acting factors. However, little is known about the in vivo …
because it affects binding of trans-acting factors. However, little is known about the in vivo …
The human-specific and smooth muscle cell-enriched LncRNA SMILR promotes proliferation by regulating mitotic CENPF mRNA and drives cell-cycle progression …
AD Mahmoud, MD Ballantyne, V Miscianinov… - Circulation …, 2019 - Am Heart Assoc
Rationale: In response to blood vessel wall injury, aberrant proliferation of vascular smooth
muscle cells (SMCs) causes pathological remodeling. However, the controlling mechanisms …
muscle cells (SMCs) causes pathological remodeling. However, the controlling mechanisms …
Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration
R Zhao, S Huang, J Li, A Gu, M Fu, W Hua… - Journal of Cell …, 2024 - rupress.org
The double-stranded RNA-binding protein Staufen1 (STAU1) regulates a variety of
physiological and pathological events via mediating RNA metabolism. STAU1 …
physiological and pathological events via mediating RNA metabolism. STAU1 …
Adenosine-to-Inosine RNA editing in cancer: molecular mechanisms and downstream targets
Abstract Adenosine-to-inosine (A-to-I), one of the most prevalent RNA modifications, has
recently garnered significant attention. The A-to-I modification actively contributes to …
recently garnered significant attention. The A-to-I modification actively contributes to …
The roles of noncoding RNAs in systemic sclerosis
Y Liu, L Cheng, H Zhan, H Li, X Li, Y Huang… - Frontiers in …, 2022 - frontiersin.org
Noncoding RNAs (ncRNAs) constitute more than 90% of the RNAs in the human genome. In
the past decades, studies have changed our perception of ncRNAs from “junk” …
the past decades, studies have changed our perception of ncRNAs from “junk” …
The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events
The double-stranded multifunctional RNA-binding protein (dsRBP) Staufen was initially
discovered in insects as a regulator of mRNA localization. Later, its mammalian orthologs …
discovered in insects as a regulator of mRNA localization. Later, its mammalian orthologs …
The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation
H Ramos, A Monette, M Niu, A Barrera… - Nucleic Acids …, 2022 - academic.oup.com
Translation initiation of the viral genomic mRNA (vRNA) of human immunodeficiency virus-
type 1 (HIV-1) can be mediated by a cap-or an internal ribosome entry site (IRES) …
type 1 (HIV-1) can be mediated by a cap-or an internal ribosome entry site (IRES) …
Transcriptional and post-transcriptional mechanisms of the development of neocortical lamination
T Popovitchenko, MR Rasin - Frontiers in Neuroanatomy, 2017 - frontiersin.org
The neocortex is a laminated brain structure that is the seat of higher cognitive capacity and
responses, long-term memory, sensory and emotional functions, and voluntary motor …
responses, long-term memory, sensory and emotional functions, and voluntary motor …