Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that
occurs either as a predictable event when an individual is exposed to toxic doses of some …

The liver is the primary organ for the metabolic degradation of xenobiotics. Transmembrane
transport proteins from the ABC and the SLC families mediate the uptake of endogenous …

Cancer is becoming more prevalent in elderly patient. Due to polypharmacy, older adults
with cancer are predisposed to drug-drug interactions. There is also an increasing interest in …

Abstract Purpose: OATP1B1 (SLCO1B1) is the most abundant and pharmacologically
relevant uptake transporter in the liver and a key mediator of xenobiotic clearance. However …

Paclitaxel is among the most widely used anticancer drugs and is known to cause a dose-
limiting peripheral neurotoxicity, the initiating mechanisms of which remain unknown. Here …

Failure to recognize important features of a drug's pharmacokinetic characteristics is a key
cause of inappropriate dose and schedule selection, and can lead to reduced efficacy and …

The current study was aimed to prepare a molecular complex of erlotinib (ERL) with
phospholipid (PC) for enhancement of solubility and thus bioavailability, therapeutic efficacy …

The overexpression of efflux transporters, especially P‐glycoprotein (Pgp, MDR1, ABCB1)
and breast cancer resistance protein (BCRP, ABCG2), represents an important mechanism …

Purpose Hyperbilirubinemia has been observed in patients treated with tyrosine kinase
inhibitor (TKI) drugs. Therefore, it would be beneficial to understand whether there is a …

Solute Carrier (SLC) transporters are a large superfamily of transmembrane carriers
involved in the regulated transport of metabolites, nutrients, ions and drugs across cellular …