Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. It is
characterized by deposition of extracellular matrix proteins, like collagen and fibronectin in …

Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …

Extracellular matrix (ECM) homeostasis is essential for normal tissue function, and its
disruption by iatrogenic injury, trauma, or disease results in fibrosis. Skin ECM homeostasis …

The differentiation of fibroblasts into a transient population of highly activated, extracellular
matrix (ECM)–producing myofibroblasts at sites of tissue injury is critical for normal tissue …

At present, the etiology of idiopathic pulmonary fibrosis (IPF) remains elusive. Over the past
two decades, however, researchers have identified and described the underlying processes …

Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular
matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically …

Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium.
Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a …

In addition to facilitating healthcare delivery planning, reliable information about prognosis is
essential for treatment decisions in patients with idiopathic pulmonary fibrosis (IPF). This …

Fibrosis is a pathologic condition characterized by excessive deposition of extracellular
matrix and chronic scaring that can affect every organ system. Organ fibrosis is associated …

Idiopathic pulmonary fibrosis (IPF) is characterized by an aberrant repair response with
uncontrolled turnover of extracellular matrix involving mesenchymal cell phenotypes, where …