Simple Summary Multielectrode array technology allows researchers to record the
spontaneous firing activity of cultured neurons over a period of multiple weeks or months …

In vitro neuronal models have become an important tool to study healthy and diseased
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …

Highlights•Overview of convergent disease mechanisms across NDDs identified in 2D & 3D
models.•Discuss therapeutic implications for various ASOs and gene editing …

Neurodevelopmental disorders (NDDs) arise from the disruption of highly coordinated
mechanisms underlying brain development, which results in impaired sensory, motor and/or …

Rett Syndrome (RTT) is a severe neurodevelopmental disorder, afflicting 1 in 10,000 female
births. It is caused by mutations in the X-linked methyl-CpG-binding protein gene (MECP2) …

Abstract The epigenetic factor Methyl-CpG-Binding Protein 2 (MeCP2) is a nuclear protein
that binds methylated DNA molecules (both 5-methylcytosine and 5-hydroxymethylcytosine) …

Multi-electrode recording of neural activity in cultures offer opportunities for understanding
how the structure of a network gives rise to function. Although it is hypothesized that network …

Background Mutations in MECP2 predominantly cause Rett syndrome and can be modeled
in vitro using human stem cell–derived neurons. Patients with Rett syndrome have signs of …

Rett syndrome (RTT) patients show abnormal developmental trajectories including loss of
language and repetitive hand movements but also have signs of cortical hyperexcitability …

Variants in the gene encoding the postsynaptic scaffolding protein SHANK2 are associated
with several neurodevelopmental disorders, including autism spectrum disorder. Here, we …