Mitochondria are not only central organelles in metabolism and energy conversion but are
also platforms for cellular signaling cascades. Classically, the shape and ultrastructure of …

Mitochondrial cristae are dynamic bioenergetic compartments whose shape changes under
different physiological conditions. Recent discoveries have unveiled the relation between …

Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction …

The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes
and plays a role in many mitochondrial processes, including respiration and energy …

Mitochondria are one of the most exhaustively investigated organelles in the cell and most
attention has been paid to the components of the mitochondrial electron transport chain …

Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …

Cardiac tissue requires a persistent production of energy in order to exert its pumping
function. Therefore, the maintenance of this function relies on mitochondria that represent …

Since it has been recognized that mitochondria are crucial not only for energy metabolism
but also for other cellular functions, there has been a growing interest in cardiolipin, the …

Among mitochondrial lipids, cardiolipin occupies a unique place. It is the only phospholipid
that is specific to mitochondria and although it is merely a minor component, accounting for …

Over the past sixty years, researchers have made outmost efforts to clarify the structural
organization and functional regulation of the complexes that configure the mitochondrial …