Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …

Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

Glycosylation is one of the most prevalent posttranslational modifications that profoundly
affects the structure and functions of proteins in a wide variety of biological recognition …

A robust, generally applicable, nongenetic technology is presented to convert monoclonal
antibodies into stable and homogeneous ADCs. Starting from a native (nonengineered) …

Glycosylation of the conserved asparagine residue in each heavy chain of IgG in the CH2
domain is known as N-glycosylation. It is one of the most common post-translational …

Glycans are the major carbon sources available to the human colonic microbiota. Numerous
N-glycosylated proteins are found in the human gut, from both dietary and host sources …

The endo-β-N-acetylglucosaminidases (ENGases) are an enzyme class (EC 3.2. 1.96)
produced by a range of organisms, ranging from bacteria, through fungi, to higher order …

Antibodies are immunoglobulins that play essential roles in immune systems. All antibodies
are glycoproteins that carry at least one or more conserved N-linked oligosaccharides (N …

Group A streptococcus (GAS) is a major bacterial pathogen responsible for both local and
systemic infections in humans. The molecular mechanisms that contribute to disease …