Canine sarcomas as a surrogate for the human disease

DL Gustafson, DL Duval, DP Regan… - Pharmacology & …, 2018 - Elsevier
Pet dogs are becoming increasingly recognized as a population with the potential to inform
medical research through their treatment for a variety of maladies by veterinary health …

[HTML][HTML] Recent and current clinical trials in canine appendicular osteosarcoma

AC Poon, A Matsuyama, AJ Mutsaers - The Canadian Veterinary …, 2020 - ncbi.nlm.nih.gov
Osteosarcoma (OSA) is an aggressive primary bone tumor in the domestic dog that most
often occurs within the appendicular skeleton. Despite the use of adjuvant chemotherapy …

Outcome and prognosis for canine appendicular osteosarcoma treated with stereotactic body radiation therapy in 123 dogs

TW Martin, L Griffin, J Custis, SD Ryan… - Veterinary and …, 2021 - Wiley Online Library
Canine appendicular osteosarcoma is commonly treated with limb amputation; however,
limb‐sparing options are frequently desired or necessary for a subset of patients. We …

Characterization of IGF2R molecular expression in canine osteosarcoma as part of a novel comparative oncology approach

C Boisclair, R Dickinson, S Giri, E Dadachova… - International Journal of …, 2023 - mdpi.com
Progress in prognostic factors, treatments, and outcome for both canine and human
osteosarcoma (OS) has been minimal over the last three decades. Surface overexpression …

Stereotactic Radiation Therapy Planning, Dose Prescription and Delivery in Veterinary Medicine: A Systematic Review on Completeness of Reporting and Proposed …

C Rohrer Bley, V Meier, M Turek… - Veterinary and …, 2024 - Wiley Online Library
Increasing numbers of dogs and cats with cancer are treated with stereotactic radiosurgery,
stereotactic radiation therapy or stereotactic body radiotherapy (SRS, SRT or SBRT). We …

Limb‐sparing in dogs using patient‐specific, three‐dimensional‐printed endoprosthesis for distal radial osteosarcoma: A pilot study

B Séguin, C Pinard, B Lussier… - Veterinary and …, 2020 - Wiley Online Library
Limb‐sparing for distal radial osteosarcoma has a high rate of complications. Using
personalized three‐dimensional (3D)‐printed implants might improve outcome. The goals of …

Comparative Molecular Characterization and Pharmacokinetics of IgG1-Fc and Engineered Fc Human Antibody Variants to Insulin-like Growth Factor 2 Receptor …

CB Prabaharan, S Giri, KJH Allen, KEM Bato… - Molecules, 2023 - mdpi.com
Novel therapeutic approaches are much needed for the treatment of osteosarcoma.
Targeted radionuclide therapy (TRT) and radioimmunotherapy (RIT) are promising …

Update in veterinary radiation oncology: focus on stereotactic radiation therapy

MW Nolan, TL Gieger - Veterinary Clinics: Small Animal …, 2019 - vetsmall.theclinics.com
Few dogs and cats with cancer are treated with radiotherapy (RT), despite increasing
availability. 1 Pet owners cite finances, distance required to travel to veterinary RT centers …

Impact of radiation dose and pre‐treatment pain levels on survival in dogs undergoing radiotherapy with or without chemotherapy for presumed extremity …

MW Nolan, NA Green, EM DiVito… - Veterinary and …, 2020 - Wiley Online Library
The purpose of this bi‐institutional retrospective study was to determine whether survival for
dogs with extremity osteosarcoma (OS) is improved through the use of stereotactic …

The adrenergic receptor antagonists propranolol and carvedilol decrease bone sarcoma cell viability and sustained carvedilol reduces clonogenic survival and …

MM Duckett, SK Phung, L Nguyen… - Veterinary and …, 2020 - Wiley Online Library
Adrenergic receptor (AR) expression has been demonstrated at several sites of primary and
metastatic tumour growth and may influence proliferation, survival, metastasis and …