Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …

Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However,
during tumour progression and metastasis, cancerous epithelial cells must adapt to and …

Transitory phenotypic changes such as the epithelial–mesenchymal transition (EMT) help
embryonic cells to generate migratory descendants that populate new sites and establish …

The transforming growth factor‐β (TGF‐β) signaling pathway mediates various biological
functions, and its dysregulation is closely related to the occurrence of malignant tumors …

Background The progression of cancer through stages that guide a benign hyperplastic
epithelial tissue towards a fully malignant and metastatic carcinoma, is driven by genetic and …

Background Tumor cells display augmented capability to maintain endoplasmic reticulum
(ER) homeostasis and hijack ER stress pathway for malignant phenotypes under …

Glioma is the most common malignant intracranial tumor and exhibits diffuse metastasis and
a high recurrence rate. The invasive property of glioma results from cell detachment. Anoikis …

Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM)
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …

Skeletal muscle loss is a detrimental side-effect of numerous chronic diseases that
dramatically increases mortality and morbidity. The alteration of protein homeostasis is …

Abstract The Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum
of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual …