Porcine reproductive and respiratory syndrome modified live virus vaccine: a “leaky” vaccine with debatable efficacy and safety

L Zhou, X Ge, H Yang - Vaccines, 2021 - mdpi.com
Porcine reproductive and respiratory syndrome (PRRS) caused by the PRRS virus (PRRSV)
is one of the most economically important diseases, that has significantly impacted the …

[HTML][HTML] Livestock disease resilience: from individual to herd level

A Doeschl-Wilson, PW Knap, T Opriessnig, SJ More - Animal, 2021 - Elsevier
Infectious diseases are a major threat to the sustainable production of high-producing
animals. Control efforts, such as vaccination or breeding approaches often target …

Modelling and assessing additional transmission routes for porcine reproductive and respiratory syndrome virus: Vehicle movements and feed ingredients

JA Galvis, CA Corzo, G Machado - … and Emerging Diseases, 2022 - Wiley Online Library
Accounting for multiple modes of livestock disease dissemination in epidemiological models
remains a challenge. We developed and calibrated a mathematical model for transmission …

Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) genetic diversity and occurrence of wild type and vaccine-like strains in the United States swine …

M Kikuti, J Sanhueza, C Vilalta, IAD Paploski… - PLoS …, 2021 - journals.plos.org
Porcine reproductive and respiratory syndrome virus genotype 2 (PRRSV-2) genetic
diversity in the US was assessed using a database comprising 10 years' worth of sequence …

Reinforcement learning methods in public health

J Weltz, A Volfovsky, EB Laber - Clinical therapeutics, 2022 - Elsevier
Purpose Reinforcement learning (RL) is the subfield of machine learning focused on optimal
sequential decision making under uncertainty. An optimal RL strategy maximizes cumulative …

Modeling suggests gene editing combined with vaccination could eliminate a persistent disease in livestock

GEL Petersen, JB Buntjer, FS Hely… - Proceedings of the …, 2022 - National Acad Sciences
Recent breakthroughs in gene-editing technologies that can render individual animals fully
resistant to infections may offer unprecedented opportunities for controlling future epidemics …

Glycoprotein 5-Derived Peptides Induce a Protective T-Cell Response in Swine against the Porcine Reproductive and Respiratory Syndrome Virus

F Calderon-Rico, A Bravo-Patiño, I Mendieta… - Viruses, 2023 - mdpi.com
We analyzed the T-cell responses induced by lineal epitopes of glycoprotein 5 (GP5) from
PRRSV to explore the role of this protein in the immunological protection mediated by T …

Modeling economic effects of vaccination against porcine reproductive and respiratory syndrome: impact of vaccination effectiveness, vaccine price, and vaccination …

B Thomann, J Rushton… - Frontiers in veterinary …, 2020 - frontiersin.org
Porcine reproductive and respiratory syndrome (PRRS) causes substantial financial losses
in pig farms and economic losses to societies worldwide. Vaccination against PRRS virus …

Phylodynamic and phylogeographic reconstruction of porcine reproductive and respiratory syndrome virus (PRRSV) in Europe: patterns and determinants

G Franzo, G Faustini, M Legnardi… - Transboundary and …, 2022 - Wiley Online Library
Porcine reproductive and respiratory syndrome (PRRS) is among the most devastating
diseases affecting the pig industry. Despite vaccines having been available for decades, the …

[HTML][HTML] Comparison of viraemia and nasal shedding after PRRSV-1 challenge following vaccination with three commercially available PRRS modified live virus …

L Hancox, M Balasch, J Angulo, E Scott-Baird… - Research in Veterinary …, 2024 - Elsevier
The effectiveness of three Porcine Reproductive and Respiratory Syndrome (PRRS)
Modified Live Virus (MLV) vaccines against PRRSV viraemia and nasal shedding following …