Quantified morphology of the cervical and subdiaphragmatic vagus nerves of human, pig, and rat

NA Pelot, GB Goldhagen, JE Cariello… - Frontiers in …, 2020 - frontiersin.org
It is necessary to understand the morphology of the vagus nerve (VN) to design and deliver
effective and selective vagus nerve stimulation (VNS) because nerve morphology influences …

Effects of short and prolonged transcutaneous vagus nerve stimulation on heart rate variability in healthy subjects

M De Couck, R Cserjesi, R Caers, WP Zijlstra… - Autonomic …, 2017 - Elsevier
The vagus nerve is strategically located in the body, and has multiple homeostatic and
health-promoting effects. Low vagal activity predicts onset and progression of diseases …

Effects of stimulus frequency, intensity, and sex on the autonomic response to transcutaneous vagus nerve stimulation

H Yokota, M Edama, R Hirabayashi, C Sekine… - Brain sciences, 2022 - mdpi.com
This study aimed to determine how transcutaneous vagus nerve stimulation (tVNS) alters
autonomic nervous activity by comparing the effects of different tVNS frequencies and …

Modeling current sources for neural stimulation in COMSOL

NA Pelot, BJ Thio, WM Grill - Frontiers in computational neuroscience, 2018 - frontiersin.org
Background: Computational modeling provides an important toolset for designing and
analyzing neural stimulation devices to treat neurological disorders and diseases. Modeling …

In vivo quantification of excitation and kilohertz frequency block of the rat vagus nerve

NA Pelot, WM Grill - Journal of neural engineering, 2020 - iopscience.iop.org
Objective. There is growing interest in treating diseases by electrical stimulation and block of
peripheral autonomic nerves, but a paucity of studies on the excitation and block of small …

Validated computational models predict vagus nerve stimulation thresholds in preclinical animals and humans

ED Musselman, NA Pelot, WM Grill - Journal of Neural …, 2023 - iopscience.iop.org
Objective. We demonstrated how automated simulations to characterize electrical nerve
thresholds, a recently published open-source software for modeling stimulation of peripheral …

Measuring and modeling the effects of vagus nerve stimulation on heart rate and laryngeal muscles

WJ Huffman, ED Musselman, NA Pelot, WM Grill - Bioelectronic Medicine, 2023 - Springer
Background Reduced heart rate (HR) during vagus nerve stimulation (VNS) is associated
with therapy for heart failure, but stimulation frequency and amplitude are limited by patient …

Implant-and anesthesia-related factors affecting cardiopulmonary threshold intensities for vagus nerve stimulation

U Ahmed, YC Chang, MF Lopez, J Wong… - Journal of Neural …, 2021 - iopscience.iop.org
Objective. Vagus nerve stimulation (VNS) is typically delivered at increasing stimulus
intensity until a neurological or physiological response is observed ('threshold') for dose …

Transcutaneous vagus nerve stimulation and extinction of prepared fear: a conceptual non-replication

AM Burger, I Van Diest, W van der Does, M Hysaj… - Scientific reports, 2018 - nature.com
Transcutaneous stimulation of the auricular branch of the vagus nerve (tVNS) may
accelerate fear extinction in healthy humans. Here, we aimed to investigate this hypothesis …

Optimization of the electrode drive pattern for imaging fascicular compound action potentials in peripheral nerve with fast neural electrical impedance tomography

E Ravagli, S Mastitskaya, N Thompson… - Physiological …, 2019 - iopscience.iop.org
Objective: The main objective of this study was to investigate which injection pattern led to
the best imaging of fascicular compound activity in fast neural EIT of peripheral nerve using …