The kidney consists of numerous cell types organized into the nephron, which is the basic
functional unit of the kidney. Any stimuli that induce loss of these cells can induce kidney …

Accompanied with the broad application of interventional therapy, the incidence of acute
kidney injury (AKI) has been recently increasing in clinical renal medicine. The …

The G-protein coupled receptors (GPCRs) activated by free fatty acids (FFAs) have emerged
as new and exciting drug targets, due to their plausible translation from pharmacology to …

Despite recent progress in the development of novel approaches to treat cancer, traditional
antineoplastic drugs, such as cisplatin, remain a mainstay of regimens targeting solid …

Abstract Background Cisplatin (Cis), carboplatin (Carb), and ifosfamide (Ifos) are common
nephrotoxic chemotherapies. Biomarkers of tubular injury may allow for early acute kidney …

Nephrotoxin exposure accounts for up to one-fourth of acute kidney injury episodes in
hospitalized patients, and the associated consequences are as severe as acute kidney …

Background: Recent attempts were made to identify early indicators of acute kidney injury
(AKI) in order to accelerate treatment and hopefully improve outcomes. This study aims to …

Introduction Platinum-based chemotherapy (PBC) is a potent antineoplastic treatment, but
cisplatin nephrotoxicity is often the limiting factor. Identifying the patients who are at risk for …

Background Acute kidney injury (AKI) is a common clinical condition directly associated with
adverse outcomes. Several AKI biomarkers have been discovered, but their use in clinical …

Acute kidney injury (AKI) limits cisplatin use. We tested whether urine cystatin C (uCyC) and
neutrophil gelatinase‐associated lipocalin (uNGAL) can preidentify patients at risk for AKI …