The concept that cancer is a metabolic disease is now well acknowledged: many cancer cell
types rely mostly on glucose and some amino acids, especially glutamine for energy supply …

Reorganization of cellular metabolism is one of the hallmarks of cancer and many tumors
show high glucose uptake and glutamine addiction. Glutamine is imported by the SLC family …

Endometrial cancer is the most common type of cancer of the female reproductive tract.
Although prognosis is generally good for patients with low-grade and early-stage diseases …

ASCT2 is an obligate exchanger of neutral amino acids, contributing to cellular amino acid
homeostasis. ASCT2 belongs to the same family (SLC1) as Excitatory Amino Acid …

Simple Summary ASCT2 and LAT1 are amino acid transporters whose impact in cancer has
been explored throughout the years. They have been associated with most currently …

Alanine-serine-cysteine transporter 2 (ASCT2, SLC1A5) is the primary transporter of
glutamine in cancer cells and regulates the mTORC1 signaling pathway. The SLC1A5 …

Glutamine metabolism, described as major energy and building blocks supply to cell growth,
has gained great attention. Alanine-Serine-Cysteine Transporter (ASCT2), which belongs to …

Prostate cancer is an androgen-dependent disease subject to interactions between the
tumor epithelium and its microenvironment. Here, we found that epigenetic changes in …

Abstract The Solute Carrier 1A (SLC1A) family includes two major mammalian transport
systems—the alanine serine cysteine transporters (ASCT1-2) and the human glutamate …

Carbon and nitrogen are essential elements for life. Glucose as a carbon source and
glutamine as a nitrogen source are important nutrients for cell proliferation. About 100 years …