Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully
produce haploid gametes. To date, only a handful of meiotic SUMO targets have been …

Transcription-related proteins are frequently identified as targets of sumoylation, including
multiple subunits of the RNA polymerase II (RNAPII) general transcription factors (GTFs) …

Sumoylation is emerging as a posttranslation modification important for regulating
chromosome duplication and stability. The origin recognition complex (ORC) that directs …

Post-translational modification by SUMO (small ubiquitin-like modifier) plays important but
still poorly understood regulatory roles in eukaryotic cells, including as a signal for …

The steady-state levels of protein sumoylation depend on relative rates of conjugation and
desumoylation. Whether SUMO modifications are generally long-lasting or short-lived is …

SUMOylation is a post-translational modification that plays critical roles in a multitude of
cellular processes including transcription, cellular localization, DNA repair and cell cycle …

Post-translational modification by the small ubiquitin-like modifier (SUMO) is an important
mechanism regulating protein function. Identification of SUMO conjugation sites on …

Ulp1 and Ulp2, in the yeast Saccharomyces cerevisiae, are the founding members of
deSUMOylating enzymes. These enzymes remove small ubiquitin-like modifier (SUMO) from …

Activation of the DNA damage checkpoint upon genotoxin treatment induces a multitude of
cellular changes, such as cell cycle arrest, to cope with genome stress. After prolonged …

Numerous proteins are sumoylated in normally growing yeast and SUMO conjugation levels
rise upon exposure to several stress conditions. We observe high levels of sumoylation also …