Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

The vimentin gene (VIM) encodes one of the 71 human intermediate filament (IF) proteins,
which are the building blocks of highly ordered, dynamic, and cell type-specific fiber …

The advancing validation and exploitation of CSF and blood neurofilament light chain
protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic …

The cytoskeleton plays an integral role in maintaining the integrity of epithelial cells.
Epithelial cells primarily employ cytokeratin in their cytoskeleton, whereas mesenchymal …

Proteins of the intermediate filament (IF) supergene family are ubiquitous structural
components that comprise, in a cell type–specific manner, the cytoskeleton proper in animal …

A global concern has emerged with the pandemic spread of Zika virus (ZIKV) infections that
can cause severe neurological symptoms in adults and newborns. ZIKV is a positive-strand …

Vimentin, an abundant cytoplasmic intermediate filament protein, is recognized for its
important role in stabilizing intracellular structure. Vimentin has been recognized for its …

Background—The vascular remodeling responsible for pulmonary arterial hypertension
(PAH) involves predominantly the accumulation of α-smooth muscle actin–expressing …

Vimentin is a protein that has been linked to a large variety of pathophysiological conditions,
including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also …