Animal models of spinal cord injury: a systematic review

M Sharif-Alhoseini, M Khormali, M Rezaei, M Safdarian… - Spinal cord, 2017 - nature.com
Study Design: PRISMA-guided systematic review. Objectives: To provide a comprehensive
framework of the current animal models for investigating spinal cord injury (SCI) and …

CatWalk-assisted gait analysis in the assessment of spinal cord injury

FPT Hamers, GC Koopmans, EAJ Joosten - Journal of neurotrauma, 2006 - liebertpub.com
Gait analysis plays an important role in the assessment of neurological function in many
disease models. In this review, we focus on the newly developed CatWalk system for gait …

Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord …

Z Liu, X Yao, W Jiang, W Li, S Zhu, C Liao… - Journal of …, 2020 - Springer
Background Inflammatory response mediated by oxidative stress is considered as an
important pathogenesis of spinal cord injury (SCI). Advanced oxidation protein products …

Pretreatment with kaempferol attenuates microglia-mediate neuroinflammation by inhibiting MAPKs–NF–κB signaling pathway and pyroptosis after secondary spinal …

Z Liu, X Yao, B Sun, W Jiang, C Liao, X Dai… - Free Radical Biology …, 2021 - Elsevier
Spinal cord injury (SCI) is a devastating injury that characterized by oxidative stress and
inflammatory response. Kaempferol is reported to be an anti-neuroinflammation in …

Designer, injectable gels to prevent transplanted Schwann cell loss during spinal cord injury therapy

LM Marquardt, VM Doulames, AT Wang, K Dubbin… - Science …, 2020 - science.org
Transplantation of patient-derived Schwann cells is a promising regenerative medicine
therapy for spinal cord injuries; however, therapeutic efficacy is compromised by inefficient …

Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury

J Sharp, J Frame, M Siegenthaler, G Nistor… - Stem …, 2010 - academic.oup.com
Evidence that cell transplants can improve recovery outcomes in spinal cord injury (SCI)
models substantiates treatment strategies involving cell replacement for humans with SCI …

Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury

JL Nielson, J Paquette, AW Liu, CF Guandique… - Nature …, 2015 - nature.com
Data-driven discovery in complex neurological disorders has potential to extract meaningful
syndromic knowledge from large, heterogeneous data sets to enhance potential for …

Prolonged human neural stem cell maturation supports recovery in injured rodent CNS

P Lu, S Ceto, Y Wang, L Graham, D Wu… - The Journal of …, 2017 - Am Soc Clin Investig
Neural stem cells (NSCs) differentiate into both neurons and glia, and strategies using
human NSCs have the potential to restore function following spinal cord injury (SCI) …

Cell death after spinal cord injury is exacerbated by rapid TNFα-induced trafficking of GluR2-lacking AMPARs to the plasma membrane

AR Ferguson, RN Christensen, JC Gensel… - Journal of …, 2008 - Soc Neuroscience
Glutamate, the major excitatory neurotransmitter in the CNS, is implicated in both normal
neurotransmission and excitotoxicity. Numerous in vitro findings indicate that the ionotropic …

Human embryonic stem cell-derived oligodendrocyte progenitor cells: preclinical efficacy and safety in cervical spinal cord injury

NC Manley, CA Priest, J Denham… - Stem cells …, 2017 - academic.oup.com
Cervical spinal cord injury (SCI) remains an important research focus for regenerative
medicine given the potential for severe functional deficits and the current lack of treatment …