Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Sarcopenia is a loss of muscle protein mass and loss of muscle function. It occurs with
increasing age, being a major component in the development of frailty. Current knowledge …

The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins),
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …

A. Genetic, molecular, and transgenic models B. Human GH rhythms III. Neuropeptide
Regulation of the GH Axis: Somatostatin and GHRH

Sarcopenia is likely a multifactorial condition that impairs physical function and predisposes
to disability. It may be prevented or treated with lifestyle interventions and pharmacological …

Purpose To summarize available evidence comparing the transdermal and the oral
administration routes of hormone replacement therapy (HRT) in postmenopausal women …

Body composition exhibits marked variations across the early human lifetime. The precise
physiological mechanisms that drive such developmental adaptations are difficult to …

Objective: To determine whether growth hormone replacement in older men improves
functional ability. Design: Randomized, controlled, double-blind trial. Setting: General …

OBJECTIVE The biological role of the adrenal sex steroid precursors‐DHEA and DHEA
sulphate (DS) and their decline with ageing remains undefined. We observed previously that …

Background and aims: The geriatric syndrome of frailty has been conceptualized as a loss of
physiologic reserve associated with endocrine dysregulation and immune dysfunction. Our …