Colorectal liver metastasis: molecular mechanism and interventional therapy
H Zhou, Z Liu, Y Wang, X Wen, EH Amador… - Signal transduction and …, 2022 - nature.com
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …
The colorectal cancer tumor microenvironment and its impact on liver and lung metastasis
Simple Summary Colorectal cancer (CRC) is the third most common cancer worldwide.
Metastasis to secondary organs, such as the liver and lungs, is a key driver of CRC-related …
Metastasis to secondary organs, such as the liver and lungs, is a key driver of CRC-related …
[HTML][HTML] The current understanding on the impact of KRAS on colorectal cancer
M Meng, K Zhong, T Jiang, Z Liu, HY Kwan… - Biomedicine & …, 2021 - Elsevier
KRAS (kirsten rat sarcoma viral oncogene) is a member of the RAS family. KRAS mutations
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …
Class I HDAC inhibitors enhance YB‐1 acetylation and oxidative stress to block sarcoma metastasis
AM El‐Naggar, SP Somasekharan, Y Wang… - EMBO …, 2019 - embopress.org
Outcomes for metastatic Ewing sarcoma and osteosarcoma are dismal and have not
changed for decades. Oxidative stress attenuates melanoma metastasis, and melanoma …
changed for decades. Oxidative stress attenuates melanoma metastasis, and melanoma …
[HTML][HTML] KRAS mutation-responsive miR-139-5p inhibits colorectal cancer progression and is repressed by Wnt signaling
F Du, T Cao, H Xie, T Li, L Sun, H Liu, H Guo… - Theranostics, 2020 - ncbi.nlm.nih.gov
Introduction: Colorectal cancer (CRC) frequently harbors KRAS mutations that result in
chemoresistance and metastasis. MicroRNAs (miRNAs) are usually dysregulated and play …
chemoresistance and metastasis. MicroRNAs (miRNAs) are usually dysregulated and play …
SP1-activated long noncoding RNA lncRNA GCMA functions as a competing endogenous RNA to promote tumor metastasis by sponging miR-124 and miR-34a in …
Y Tian, R Ma, Y Sun, H Liu, H Zhang, Y Sun, L Liu, Y Li… - Oncogene, 2020 - nature.com
Long noncoding RNAs (lncRNAs) were demonstrated to play important roles in gene
regulation and cancer progression. However, the functional roles of lncRNAs and the …
regulation and cancer progression. However, the functional roles of lncRNAs and the …
Patient-level proteomic network prediction by explainable artificial intelligence
Understanding the pathological properties of dysregulated protein networks in individual
patients' tumors is the basis for precision therapy. Functional experiments are commonly …
patients' tumors is the basis for precision therapy. Functional experiments are commonly …
[HTML][HTML] The excitable signal transduction networks: movers and shapers of eukaryotic cell migration
In response to a variety of external cues, eukaryotic cells display varied migratory modes to
perform their physiological functions during development and in the adult. Aberrations in cell …
perform their physiological functions during development and in the adult. Aberrations in cell …
Circ_0001658 promotes the proliferation and metastasis of osteosarcoma cells via regulating miR‐382‐5p/YB‐1 axis
L Wang, P Wang, X Su, B Zhao - Cell biochemistry and function, 2020 - Wiley Online Library
Circular RNA (circRNA) can modulate the gene expression via sponging microRNA
(miRNA) in multiple malignancies. Nevertheless, the detailed function of circ_0001658 in …
(miRNA) in multiple malignancies. Nevertheless, the detailed function of circ_0001658 in …
Enhanced YB1/EphA2 axis signaling promotes acquired resistance to sunitinib and metastatic potential in renal cell carcinoma
H Ruan, S Li, L Bao, X Zhang - Oncogene, 2020 - nature.com
VHL mutations are the most common tumorigenic lesions in clear cell renal cell carcinoma
(ccRCC) and result in continued activation of the HIF/VEGF pathway and uncontrolled …
(ccRCC) and result in continued activation of the HIF/VEGF pathway and uncontrolled …