Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or
the rectum. A growing number of researches prove that the unfolded protein response (UPR) …

Melanoma is the most lethal skin cancer with rising incidence worldwide. Despite significant
advances in target therapy and immunotherapy, low response rates and the development of …

Autophagic degradation of the endoplasmic reticulum (ER-phagy) is triggered by ER stress
in diverse organisms. However, molecular mechanisms governing ER stress-induced ER …

The unfolded protein response (UPR) is an evolutionarily conserved adaptive response
triggered by the stress of the endoplasmic reticulum (ER) due, among other causes, to …

Background Our previous study showed that calreticulin (CRT) promoted EGF-induced
epithelial-mesenchymal transition (EMT) in pancreatic cancer (PC) via Integrin/EGFR …

Inositol-requiring enzyme 1 α (IRE1α) is a type I transmembrane protein that resides in the
endoplasmic reticulum (ER). IRE1α, which is the primary sensor of ER stress, has been …

The endoplasmic reticulum (ER) organelle is the key intracellular site of both protein and
lipid biosynthesis. ER dysfunction, termed ER stress, can result in protein accretion within …

Abstract HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding) RNases are an
emerging class of functionally diverse RNA processing and degradation enzymes. Members …

3‐3σ functions as an oncogene in colorectal cancer and is associated with therapy
resistance. However, the mechanisms underlying these observations are not clear. The …

Pancreatic cancer (PC) is one of the most aggressive malignancies, characterized by an
increasing incidence and unfavorable prognosis. Despite recent advances, surgical …