Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase
with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a …

Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

The ubiquitin proteasome system (UPS) degrades misfolded proteins including those
implicated in neurodegenerative diseases. We investigated the effects of tau accumulation …

Direct interactions between proteins are essential for the regulation of their functions in
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …

Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …

The pathophysiological link between type 2 diabetes mellitus (T2DM) and Alzheimer's
disease (AD) has been suggested in several reports. Few findings suggest that T2DM has …

There is increasing interest in the role that anesthetic agents might play in the etiology of
postoperative cognitive dysfunction (POCD). Recent animal studies suggest that acute …

J. Neurochem.(2010) 112, 1353–1367. Abstract We are analyzing the physiological function
of Tau protein and its abnormal pathological behavior when this protein is self‐assemble …

Oxidative stress has been implicated in the pathogenesis of a number of diseases including
Alzheimer's disease (AD). The oxidative stress hypothesis of AD pathogenesis, in part, is …

Tauopathies are age-related neurodegenerative diseases that are characterized by the
presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered …