[HTML][HTML] Lithium Ions as Modulators of Complex Biological Processes: The Conundrum of Multiple Targets, Responsiveness and Non-Responsiveness, and the …

DA Hart - Biomolecules, 2024 - mdpi.com
Lithium is one of the lightest elements on Earth and it has been in the environment since the
formation of the galaxy. While a common element, it has not been found to be an essential …

Personalized 3-gene panel for prostate cancer target therapy

S Iacobas, DA Iacobas - Current Issues in Molecular Biology, 2022 - mdpi.com
Many years and billions spent for research did not yet produce an effective answer to
prostate cancer (PCa). Not only each human, but even each cancer nodule in the same …

Altered Hippocampal and Striatal Expression of Endothelial Markers and VIP/PACAP Neuropeptides in a Mouse Model of Systemic Lupus Erythematosus

J Lee, S Thomas Broome, MI Jansen… - International Journal of …, 2023 - mdpi.com
Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most common and
severe manifestations of lupus; however, its pathogenesis is still poorly understood. While …

Metabolic deregulation in pulmonary hypertension

R Mathew, S Iacobas, J Huang, DA Iacobas - Current Issues in Molecular …, 2023 - mdpi.com
The high morbidity and mortality rate of pulmonary arterial hypertension (PAH) is partially
explained by metabolic deregulation. The present study complements our previous …

Theory and applications of the (Cardio) genomic fabric approach to post-ischemic and hypoxia-induced heart failure

DA Iacobas, L Xi - Journal of Personalized Medicine, 2022 - mdpi.com
The genomic fabric paradigm (GFP) characterizes the transcriptome topology by the
transcripts' abundances, the variability of the expression profile, and the inter-coordination of …

Reduced miR-99a-3p levels in systemic lupus erythematosus may promote B cell proliferation via NCAPG and the PI3K/AKT signaling pathway

Q Zhu, Y Zhou, M Yang, B Yang, W Cao, L Yuan… - Lupus, 2024 - journals.sagepub.com
Background Systemic lupus erythematosus is an immunologically dysregulated disease
characterized by the presence of multiple autoantibodies. In SLE, B lymphocytes contribute …

Personalized 1-2-3-Gene (s) Tickets to Cancer-Free Prostate

S Iacobas, DA Iacobas - 2021 - preprints.org
Many years and $$$ spent for research did not yet produced a universally effective gene
therapy of prostate cancer (PCa). Our studies indicated that not only each human, but even …