Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and
diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial …

The only known function of NAD (P) H oxidases is to produce reactive oxygen species
(ROS). Skeletal muscles express three isoforms of NAD (P) H oxidases (Nox1, Nox2, and …

Patients with autosomal recessive protein kinase C δ (PKCδ) deficiency suffer from
childhood-onset autoimmunity, including systemic lupus erythematosus. They also suffer …

Background: SARS-CoV-2 is associated with an increased risk of venous and arterial
thrombosis, but the underlying mechanism is still unclear. Methods: We performed a cross …

Coronary microvascular endothelial cells (CMECs) react to changes in coronary blood flow
and myocardial metabolites and regulate coronary blood flow by balancing vasoconstrictors …

Gout is a common inflammatory disease. The activation of NLRP3 inflammasome induced
by monosodium urate (MSU) crystals has a critical role in gout, and its prevention is …

Senescent cells withdraw from the cell cycle and do not proliferate. The prevalence of
senescent compared to normally functioning parenchymal cells increases with age …

The enzymatic complex Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase
(NOx) may be the principal source of reactive oxygen species (ROS). The NOX2 and NOX4 …

The participation of reactive oxygen species (ROS) generated by NOX1 and NOX2/NADPH
oxidase has been documented during inflammatory pain. However, the molecular …