19F NMR has emerged as a powerful tool in drug discovery, particularly in fragment-based
screens. The favorable magnetic resonance properties of the fluorine-19 nucleus, the …

Structural alterations of NUTM1 were originally thought to be restricted to poorly
differentiated carcinomas with variable squamous differentiation originating in the midline …

Erlotinib, an EGFR tyrosine kinase inhibitor, is used for treating patients with cancer
exhibiting EGFR overexpression or mutation. However, the response rate of erlotinib is low …

Conspectus Inhibitor discovery for protein–protein interactions has proven difficult due to the
large protein surface areas and dynamic interfaces involved. This is particularly the case …

The free energy of a process is the fundamental quantity that determines its spontaneity or
propensity at a given temperature. In particular, the binding free energy of a drug candidate …

Nucleosome remodeling provides access to genomic DNA for recruitment of the
transcriptional machinery to mediate gene expression. The aberrant function of nucleosome …

Fragment-based ligand discovery has been successful in targeting diverse proteins. Despite
drug-like molecules having more 3D character, traditional fragment libraries are largely …

The dysfunctional bromodomain PHD finger transcription factor (BPTF) exerts a pivotal
influence in the occurrence and development of many human diseases, particularly cancers …

The nucleosome remodeling factor (NURF) alters chromatin accessibility through
interactions with its largest subunit, the bromodomain PHD finger transcription factor BPTF …

Bromodomain-containing proteins regulate transcription through protein–protein interactions
with chromatin and serve as scaffolding proteins for recruiting essential members of the …