Exploration of new drug-like inhibitors for serine/threonine protein phosphatase 5 of Plasmodium falciparum: a docking and simulation study

S Gupta, A Jadaun, H Kumar, U Raj… - Journal of …, 2015 - Taylor & Francis
Protein phosphorylation is an important mechanism that implicates in physiology of any
organism including parasitic protozoa. Metallic protein Ser/Thr protein phosphatase 5 (PP5) …

Ribavirin suppresses bacterial virulence by targeting LysR-type transcriptional regulators

RS Mandal, A Ta, R Sinha, N Theeya, A Ghosh… - Scientific reports, 2016 - nature.com
Targeting bacterial virulence mechanisms without compromising bacterial growth is a
promising strategy to prevent drug resistance. LysR-type transcriptional regulators (LTTRs) …

Multitargeting: An Alternative Approach to Tackle Multidrug Resistance in Tuberculosis

S Hazra, R Hazarika, S Patra - Current Drug Targets, 2023 - ingentaconnect.com
Background: The prevalence of drug-resistant organisms has steadily increased over the
past few decades worldwide. Especially in tuberculosis (TB) disease, the problems of co …

Mechanical forces between mycobacterial antigen 85 complex and fibronectin

A Viljoen, D Alsteens, Y Dufrêne - Cells, 2020 - mdpi.com
Adhesion to extracellular matrix proteins is an important first step in host invasion, employed
by many bacterial pathogens. In mycobacteria, the secreted Ag85 complex proteins …

In silico identification of potential drug compound against Peroxisome proliferator-activated receptor-gamma by virtual screening and toxicity studies for the treatment …

S Singh, A Mohanty - Journal of Biomolecular Structure and …, 2018 - Taylor & Francis
Diabetic Nephropathy is a serious complication of diabetes mellitus. Current therapeutic
strategies of Diabetic Nephropathy are based on control of modifiable risks like …

PLS-DA SIM WHO World Health Organization XCMS XCMS

U Srivastava, S Kanchan, M Kesheri… - … : Recent Advances and …, 2023 - books.google.com
Life sciences are currently transformed by the developments in molecular biologybased
analysis [55, 56], which include important advances in the instrumental analysis as well …

Secondary and tertiary structure prediction of proteins: a bioinformatic approach

M Kesheri, S Kanchan, S Chowdhury… - … System Modelling and …, 2015 - Springer
Correct prediction of secondary and tertiary structure of proteins is one of the major
challenges in bioinformatics/computational biological research. Predicting the correct …

Issues with the current drugs for Mycobacterium tuberculosis cure and potential of cell envelope proteins for new drug discovery

PS Mahajan, P Girigosavi, V Chauware… - Indian Journal of …, 2023 - Elsevier
Mycobacterium tuberculosis has been the smartest pathogen ever and a challenge to drug
development. Its replicative machinery is unique, so targeting the same for killing the …

Nutrimetabolomics: Metabolomics in Nutrition Research

U Srivastava, S Kanchan, M Kesheri… - … : Recent Advances and …, 2023 - Springer
Nutrimetabolomics is a field of study that focuses on the analysis of small molecules in
biological samples such as blood, urine, and tissues, to understand the relationship …

Exploring interaction of TNF and orthopoxviral CrmB protein by surface plasmon resonance and free energy calculation

NV Ivanisenko, TV Tregubchak… - Protein and Peptide …, 2014 - ingentaconnect.com
Inhibition of the activity of the tumor necrosis factor (TNF) has become the main strategy for
treating inflammatory diseases. The orthopoxvirus TNF-binding proteins can bind and …