The 70-kDa heat shock protein (HSP70) family of molecular chaperones represents one of
the most ubiquitous classes of chaperones and is highly conserved in all organisms …

Background: The aging phenotype in humans is very heterogeneous and can be described
as a complex mosaic resulting from the interaction of a variety of environmental, stochastic …

BACKGROUND: A sexual dimorphism in human life expectancy has existed in almost every
country for as long as records have been kept. Although human life expectancy has …

Heat shock proteins (HSPs) are, in general, prosurvival molecules within the cellular
environment, and the overexpression of even just 1 family of HSPs can lead to protection …

Researchers have only just begun to elucidate the relationship between heat shock proteins
(HSP) and Toll-like receptors (TLR). HSP were originally described as an intracellular …

As an intracellular polypeptide, heat shock protein 70 (HSP70) can be exposed on the
plasma membrane and/or released into the circulation. However, the role of HSP70 in …

From its original description as solely an intracellular molecular chaperone, heat shock
proteins have now been shown to function as initiators of the host's immune response …

Integrative physiology studies have shown that immune system and central nervous system
interplay very closely towards behavioural modulation. Since the 70‐kDa heat shock …

Currently two mechanisms are recognized by which heat shock proteins (HSP) are released
from cells; a passive release mechanism, including necrotic cell death, severe blunt trauma …

Neurodegenerative diseases are largely defined by protein aggregates in affected tissues.
Aggregates contain some shared components as well as proteins thought to be specific for …