Vaccine adjuvants: mechanisms and platforms

T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

New-age vaccine adjuvants, their development, and future perspective

SK Verma, P Mahajan, NK Singh, A Gupta… - Frontiers in …, 2023 - frontiersin.org
In the present scenario, immunization is of utmost importance as it keeps us safe and
protects us from infectious agents. Despite the great success in the field of vaccinology …

Adjuvant physiochemistry and advanced nanotechnology for vaccine development

H Ren, W Jia, Y Xie, M Yu, Y Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …

Challenges in developing personalized neoantigen cancer vaccines

PD Katsikis, KJ Ishii, C Schliehe - Nature Reviews Immunology, 2024 - nature.com
The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

Probiotics and gut microbiota: Mechanistic insights into gut immune homeostasis through TLR pathway regulation

H Kaur, SA Ali - Food & Function, 2022 - pubs.rsc.org
Consumption of probiotics as a useful functional food improves the host's wellbeing, and,
when paired with prebiotics (indigestible dietary fibre/carbohydrate), often benefits the host …

Rational design of T-cell-and B-cell-based therapeutic cancer vaccines

WH Li, JY Su, YM Li - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus Cancer vaccines provide an efficient strategy to enhance tumor-specific
immune responses by redeploying immune systems. Despite the approval of the first cancer …

mRNA-based therapeutics in cancer treatment

H Sun, Y Zhang, G Wang, W Yang, Y Xu - Pharmaceutics, 2023 - mdpi.com
Over the past two decades, significant technological innovations have led to messenger
RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic …

Q fever immunology: the quest for a safe and effective vaccine

G Sam, J Stenos, SR Graves, BHA Rehm - npj Vaccines, 2023 - nature.com
Q fever is an infectious zoonotic disease, caused by the Gram-negative bacterium Coxiella
burnetii. Transmission occurs from livestock to humans through inhalation of a survival form …

Progress towards adjuvant development: focus on antiviral therapy

A Brai, F Poggialini, C Pasqualini, CI Trivisani… - International Journal of …, 2023 - mdpi.com
In recent decades, vaccines have been extraordinary resources to prevent pathogen
diffusion and cancer. Even if they can be formed by a single antigen, the addition of one or …

Vaccination strategies based on bacterial self-assembling proteins as antigen delivery nanoscaffolds

F Lamontagne, V Khatri, P St-Louis, S Bourgault… - Vaccines, 2022 - mdpi.com
Vaccination has saved billions of human lives and has considerably reduced the economic
burden associated with pandemic and endemic infectious diseases. Notwithstanding major …