Cardiac hypertrophy is one of the main ways in which cardiomyocytes respond to
mechanical and neurohormonal stimuli. It enables myocytes to increase their work output …

Lipopolysaccharide is a component of the gram-negative bacterial cell wall that is
responsible for 25,000-50,000 deaths in the United States each year. The sequelae of gram …

The deleterious effects of lipopolysaccharide (LPS) during endotoxic shock are associated
with the secretion of tumor necrosis factor (TNF) and the production of nitric oxide (NO), both …

Background & Aims: Decreased cardiac contractility and β-adrenergic responsiveness have
been observed in cirrhosis, but the etiology remains unclear. We aimed to test the role of …

Nitric oxide (NO) has emerged as a novel regulator of several ovarian events, such as
ovulation, steroidogenesis, and apoptotic cell death. The NO synthases (NOS) are a family …

Sepsis is the leading cause of mortality in critically ill patients. In this pathological syndrome,
septic shock and sequential multiple organ failure correlate with poor outcome. The …

Sepsis is a heterogeneous class of syndromes caused by a systemic inflammatory response
to infection. Septic shock, a severe form of sepsis, is associated with the development of …

The enzyme heme oxygenase (HO), which exists in inducible (HO-1) and constitutive (HO-2)
isoforms, degrades heme to biliverdin and CO. CO depresses cardiac contraction via cGMP …

Endothelial dysfunction is a characteristic of, and may be pathogenic in, inflammatory
cardiovascular diseases, including sepsis. The mechanism underlying inflammation …

Matrix metalloproteinases (MMPs) are a family of proteases best known for their capacity to
proteolyse several proteins of the extracellular matrix. Their increased activity contributes to …