Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens

Y Lu, Q Pan, W Gao, Y Pu, K Luo, B He, Z Gu - Biomaterials, 2022 - Elsevier
Disulfiram (DSF) has been used as an alcoholism drug for 70 years. Recently, it has
attracted increasing attention owing to the distinguished anticancer activity, which can be …

Advancing cancer therapy with copper/disulfiram nanomedicines and drug delivery systems

X Kang, S Jadhav, M Annaji, CH Huang, R Amin… - Pharmaceutics, 2023 - mdpi.com
Disulfiram (DSF) is a thiocarbamate based drug that has been approved for treating
alcoholism for over 60 years. Preclinical studies have shown that DSF has anticancer …

[HTML][HTML] Copper-cysteamine nanoparticle-mediated microwave dynamic therapy improves cancer treatment with induction of ferroptosis

H Zhou, Z Liu, Z Zhang, NK Pandey, E Amador… - Bioactive Materials, 2023 - Elsevier
Photodynamic Therapy (PDT) holds a great promise for cancer patients, however, due to the
hypoxic characteristics of most solid tumors and the limited penetration depth of light in …

Exploration of copper-cysteamine nanoparticles as an efficient heterogeneous Fenton-like catalyst for wastewater treatment

NK Pandey, HB Li, L Chudal, B Bui, E Amador… - Materials Today …, 2022 - Elsevier
Abstract Copper-cysteamine (Cu-Cy) is a new nanoparticle that can be stimulated by UV
light, microwaves, X-rays, and ultrasound to produce various types of reactive oxygen …

[HTML][HTML] Second near-infrared nanomaterials for cancer photothermal immunotherapy

H Shang, J Wu, X Liu, Y Tong, Y He, Q Huang… - Materials Today …, 2023 - Elsevier
Photothermal immunotherapy has drawn worldwide attentions for malignant tumors based
on noninvasive methods of nanomaterials and immune-associated drugs in the past years …

[HTML][HTML] Oxidative stress-induced gastrointestinal diseases: Biology and nanomedicines—A Review

M Rezvani - BioChem, 2024 - mdpi.com
Gastrointestinal diseases have been among the main concerns of medical and scientific
societies for a long time. Several studies have emphasized the critical role of oxidative stress …

A new type of cuprous-cysteamine sensitizers: Synthesis, optical properties and potential applications

Y Wang, ND Alkhaldi, NK Pandey, L Chudal… - Materials Today …, 2021 - Elsevier
Herein, for the first time, we report a series of cuprous-cysteamine (Cu-Cy-X, X= F, Cl, Br,
and I)) sensitizers that possess tunable fluorescence from orange to yellow. The Cu-Cy-X …

Multifaceted role of NF-κB in hepatocellular carcinoma therapy: Molecular landscape, therapeutic compounds and nanomaterial approaches

R Gupta, MM Kadhim, AT Jalil, AM Obayes… - Environmental …, 2023 - Elsevier
The predominant kind of liver cancer is hepatocellular carcinoma (HCC) that its treatment
have been troublesome difficulties for physicians due to aggressive behavior of tumor cells …

Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance

S Fakhri, SZ Moradi, F Faraji, T Farhadi… - Cancer and Metastasis …, 2023 - Springer
The tumor microenvironment (TME) plays a pivotal role in cancer development and
progression. In this line, revealing the precise mechanisms of the TME and associated …

[HTML][HTML] Dual-responsive metal organic framework for electrically-enhanced cascade catalytic tumor therapy

J Zhao, L Liu, L Gu, Z Li, Y Li, Z Wu, B Sun… - Materials Today …, 2023 - Elsevier
Chemodynamic Therapy (CDT) based on Fenton reaction that can produce highly toxic
reactive oxygen species to kill cancer cells has attracted considered attention. However, the …