Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

During Parkinson's disease (PD), both the central nervous system (CNS) and peripheral
nervous system (PNS) are affected. In parallel, innate immune cells respond early to …

Telomere attrition is a proposed hallmark of aging. To evaluate the association of telomere
length (TL) with chronological age across the human lifespan, we conducted a systematic …

Cellular senescence has gained increasing interest during recent years, particularly due to
causal involvement in the aging process corroborated by multiple experimental findings …

Patients with Parkinson's disease (PD) exhibit distinct gut microbiota, which may promote
gut-derived inflammation. Rifaximin is a nonabsorbable antibiotic that can modify gut …

Peripheral inflammatory immune responses are thought to play a major role in the
pathogenesis of Parkinson's disease (PD). The neutrophil-to-lymphocyte ratio (NLR), a …

Given the clear role of inflammation in the pathogenesis of Parkinson's disease (PD) and its
impact on incidence and phenotypical characteristics, this review provides an overview with …

Protective effects of the telomerase protein TERT have been shown in neurons and brain.
We previously demonstrated that TERT protein can accumulate in mitochondria of …

The study of cell senescence is a burgeoning field. Senescent cells can modify the cellular
microenvironment through the secretion of a plethora of biologically active products referred …

Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder
characterized by motor and non-motor disturbances as a result of a complex and not fully …