More than 75 million people worldwide have been infected with human immunodeficiency
virus (HIV), and there are now approximately 37 million individuals living with the infection …

The course of immune maturation has evolved to favour survival at each stage of
development in early life. Fetal and neonatal immune adaptations facilitate intrauterine …

In addition to direct effects on virus infectivity, antibodies mediate antibody-dependent
cellular cytotoxicity (ADCC), the killing of an antibody-coated virus-infected cell by cytotoxic …

The developing immune system is adapted to the exposure to a plethora of pathogenic and
non-pathogenic antigens encountered in utero and after birth, requiring a fine balance …

Objective: Cytomegalovirus (CMV) coinfection may influence HIV-1 disease progression
during infancy. Our aim was to describe the incidence of CMV infection and the kinetics of …

A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …

A low complexity diagnostic test that rapidly and reliably detects HIV infection in infants at
the point of care could facilitate early treatment, improving outcomes. However, many infant …

Abstract Background. South African guidelines recommend protease-inhibitor-based
antiretroviral therapy (ART) with lopinavir-ritonavir for human immunodeficiency virus (HIV) …

Highly mutable infectious disease pathogens (hm-IDPs) such as HIV and influenza evolve
faster than the human immune system can contain them, allowing them to circumvent …

Background: Virologic and immunologic responses to antiretroviral treatment (ART) in
infants may differ from older children due to immunologic, clinical, or epidemiologic …