Bestrophin-1 is an integral membrane protein, encoded by the BEST1 gene, which is
located in the basolateral membrane of the retinal pigment epithelium. The bestrophin-1 …

This article reviews the current state of knowledge about the bestrophins, a newly identified
family of proteins that can function both as Cl− channels and as regulators of voltage-gated …

Over the 15 years since the original description, optical coherence tomography (OCT) has
become one of the key diagnostic technologies in the ophthalmic subspecialty areas of …

The inherited macular dystrophies comprise a heterogeneous group of disorders
characterised by central visual loss and atrophy of the macula and underlying retinal …

Bestrophin-1 is preferentially expressed at the basolateral membrane of the retinal
pigmented epithelium (RPE) of the retina. Mutations in the BEST1 gene cause the retinal …

Bestrophinopathies, one of the most common forms of inherited macular degenerations, are
caused by mutations in the BEST1 gene expressed in the retinal pigment epithelium (RPE) …

purpose. To assess photoreceptor morphology in patients with Stargardt's disease and
fundus flavimaculatus using ultrahigh-resolution optical coherence tomography (UHR-OCT) …

PURPOSE: To investigate and integrate the photographic, angiographic, and tomographic
findings from a group of patients with various stages of vitelliform macular dystrophy type 2 …

Mutations in the BEST1 gene cause detachment of the retina and degeneration of
photoreceptor (PR) cells due to a primary channelopathy in the neighboring retinal pigment …

There are four members of the bestrophin family of proteins in the human genome, of which
two are known to be expressed in the eye. The gene BEST1 (formerly VMD2) which …