Cells undergo apoptosis in development, tissue homeostasis, and disease and are
subsequently cleared by professional and nonprofessional phagocytes. There is now …

Thy‐1 or CD90 is a glycophosphatidylinositol‐linked glycoprotein expressed on the surface
of neurons, thymocytes, subsets of fibroblasts, endothelial cells, mesangial cells and some …

Mesangial cells-mediated glomerulonephritis is a frequent cause of end-stage renal
disease. Here, we show that celastrol is effective in treating both reversible and irreversible …

Macrophage infiltration of the kidney is a prominent feature associated with the severity of
renal injury and progressive renal failure. To determine the influence of macrophages in …

On infiltrating inflamed tissue, macrophages respond to the local microenvironment and
develop one of two broad phenotypes: classically activated (M1) macrophages that cause …

Multiple facets of macrophages in renal injury. Macrophage infiltration is a common feature
of renal disease and their presence has been synonymous with tissue damage and …

This review provides an overview of the current understanding of the biology of monocytes
and macrophages. It focuses on four rapidly advancing areas that underpin recent …

Infiltrating macrophages (mϕ) can cause injury or facilitate repair, depending on how they
are activated by the microenvironment. Studies in vitro have defined the roles of individual …

An understanding of the role of macrophages at different time-points in renal inflammation,
and the development of techniques for modulating macrophage activation in vivo, will …

Macrophages are important mediators of injury in most types of human kidney diseases;
however, the pathogenic importance of both macrophage number and activation status is …