The initiation and maintenance of reproductive capacity in humans is dependent on pulsatile
secretion of the hypothalamic hormone GnRH. Congenital hypogonadotropic hypogonadism …

Adolescence is a transitional period of physical and behavioral development between
childhood and adulthood. Puberty is a distinct period of sexual maturation that occurs during …

Objective To evaluate whether body size in early life has an independent effect on risk of
disease in later life or whether its influence is mediated by body size in adulthood. Design …

Importance The association between increasing body mass index (BMI; calculated as weight
in kilograms divided by height in meters squared) and risk of breast cancer is unique in …

During the past decade, possible advancement in timing of puberty has been reported in the
United States. In addition, early pubertal development and an increased incidence of sexual …

The measurement of puberty is an intricate and precise task, requiring a match between
participants' developmental age and appropriate techniques to identify and capture …

Menarche is a milestone in a woman's life as it denotes the start of reproductive capacity.
Aim of this report is to review the recent developments and the current knowledge in the …

The parents of a 6-year-old girl bring her to a pediatrician because of breast development.
Her medical history is unremarkable. The parents are of average height, and the mother …

Young patients and their parents often are unsure about what represents normal menstrual
patterns, and clinicians also may be unsure about normal ranges for menstrual cycle length …

Since the early 1980s, the focus on the importance of puberty to adolescent development
has continued with variability in the methodology selected to measure puberty. To capture …