Compartmentalization and transporter engineering strategies for terpenoid synthesis

K Jin, H Xia, Y Liu, J Li, G Du, X Lv, L Liu - Microbial Cell Factories, 2022 - Springer
Microbial cell factories for terpenoid synthesis form a less expensive and more environment-
friendly approach than chemical synthesis and extraction, and are thus being regarded as …

The similarity between N-terminal targeting signals for protein import into different organelles and its evolutionary relevance

M Kunze, J Berger - Frontiers in physiology, 2015 - frontiersin.org
The proper distribution of proteins between the cytosol and various membrane-bound
compartments is crucial for the functionality of eukaryotic cells. This requires the cooperation …

Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact

N Shai, E Yifrach, CWT van Roermund… - Nature …, 2018 - nature.com
The understanding that organelles are not floating in the cytosol, but rather held in an
organized yet dynamic interplay through membrane contact sites, is altering the way we …

[HTML][HTML] MULocDeep: a deep-learning framework for protein subcellular and suborganellar localization prediction with residue-level interpretation

Y Jiang, D Wang, Y Yao, H Eubel, P Künzler… - Computational and …, 2021 - Elsevier
Prediction of protein localization plays an important role in understanding protein function
and mechanisms. In this paper, we propose a general deep learning-based localization …

Peroxisomes are juxtaposed to strategic sites on mitochondria

Y Cohen, YA Klug, L Dimitrov, Z Erez… - Molecular …, 2014 - pubs.rsc.org
Peroxisomes are ubiquitous and dynamic organelles that house many important pathways
of cellular metabolism. In recent years it has been demonstrated that mitochondria are tightly …

Illumination of the spatial order of intracellular pH by genetically encoded pH-sensitive sensors

M Benčina - Sensors, 2013 - mdpi.com
Fluorescent proteins have been extensively used for engineering genetically encoded
sensors that can monitor levels of ions, enzyme activities, redox potential, and metabolites …

Functional translational readthrough: a systems biology perspective

F Schueren, S Thoms - PLoS genetics, 2016 - journals.plos.org
Translational readthrough (TR) has come into renewed focus because systems biology
approaches have identified the first human genes undergoing functional translational …

Pex19 is involved in importing dually targeted tail‐anchored proteins to both mitochondria and peroxisomes

BA Cichocki, K Krumpe, DG Vitali, D Rapaport - Traffic, 2018 - Wiley Online Library
Tail‐anchored (TA) proteins are embedded into their corresponding membrane via a single
transmembrane segment at their C‐terminus whereas the majority of the protein is facing the …

mRNA targeting, transport and local translation in eukaryotic cells: from the classical view to a diversity of new concepts

KA Lashkevich, SE Dmitriev - Molecular Biology, 2021 - Springer
Spatial organization of protein biosynthesis in the eukaryotic cell has been studied for more
than fifty years, thus many facts have already been included in textbooks. According to the …

Anaerobic peroxisomes in Entamoeba histolytica metabolize myo-inositol

Z Verner, V Žárský, T Le, RK Narayanasamy… - PLoS …, 2021 - journals.plos.org
Entamoeba histolytica is believed to be devoid of peroxisomes, like most anaerobic protists.
In this work, we provided the first evidence that peroxisomes are present in E. histolytica …