At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-
associated domains (LADs) aid functional organization of the genome. We review the …

Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …

Background Infertility is a common reproductive disorder, with male factor infertility
accounting for approximately half of all cases. Taking a paternal perceptive, recent research …

Chromatin is a dynamic structure composed of DNA, RNA, and proteins, regulating storage
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …

Simple Summary The aim of this review is to summarize lamin A/C's currently known
functions in both normal and diseased cells. Lamin A/C is a nuclear protein with many …

In mammalian interphase nuclei, more than one thousand large genomic regions are
positioned at the nuclear lamina (NL). These lamina‐associated domains (LAD s) are …

Background B-type lamins are critical nuclear envelope proteins that interact with the three-
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …

Cancers and developmental disorders are associated with alterations in the 3D genome
architecture in space and time (the fourth dimension). Mammalian 3D genome organization …

The evolution of DNA methylome and methylation intra-tumor heterogeneity (ITH) during
early carcinogenesis of lung adenocarcinoma has not been systematically studied. We …

In recent years, our perspective on the cell nucleus has evolved from the view that it is a
passive but permeable storage organelle housing the cell's genetic material to an …