Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

BACKGROUND: The cytosolic glutathione transferases (GSTs) comprise a super family of
proteins that can be categorized into multiple classes with a mixture of highly specific and …

Macrophages play a key role in both normal and pathological processes involving immune
and inflammatory responses, to a large extent through their capacity to secrete a wide range …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

Searches with the human Omega glutathione transferase (GST) identified two outlying
groups of the GST superfamily in Arabidopsis thaliana which differed from all other plant …

Background Cancer‐related weight loss is associated with increased inflammation and
decreased survival. The novel inflammatory mediator growth differentiation factor (GDF) 15 …

As part of a study to identify novel genes associated with macrophage activation, we have
cloned a new member of the transforming growth factor β (TGF‐β) superfamily designated …

In recent decades, growing scientific evidence supports the role of ion channels in the
development of different cancers. Both potassium selective pores and chloride …

Most proteins adopt a well defined three-dimensional structure; however, it is increasingly
recognized that some proteins can exist with at least two stable conformations. Recently, a …

The ubiquitous glutathione transferases (GSTs) catalyze glutathione conjugation to many
compounds and have other diverse functions that continue to be discovered. We noticed …