Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies
Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
Post-translational modifications of G Protein–Coupled receptors control cellular signaling dynamics in space and time
G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours
Checkpoint blockade therapy targeting the programmed-death ligand 1 (PD-L1) and its
receptor programmed cell death 1 promotes T-cell-mediated immunosurveillance against …
receptor programmed cell death 1 promotes T-cell-mediated immunosurveillance against …
MusiteDeep: a deep-learning based webserver for protein post-translational modification site prediction and visualization
MusiteDeep is an online resource providing a deep-learning framework for protein post-
translational modification (PTM) site prediction and visualization. The predictor only uses …
translational modification (PTM) site prediction and visualization. The predictor only uses …
Engineering extracellular vesicles enriched with palmitoylated ACE2 as COVID‐19 therapy
F Xie, P Su, T Pan, X Zhou, H Li, H Huang… - Advanced …, 2021 - Wiley Online Library
Abstract Angiotensin converting enzyme 2 (ACE2) is a key receptor present on cell surfaces
that directly interacts with the viral spike (S) protein of the severe acute respiratory syndrome …
that directly interacts with the viral spike (S) protein of the severe acute respiratory syndrome …
[PDF][PDF] A Ca2+-sensor switch for tolerance to elevated salt stress in Arabidopsis
L Steinhorst, G He, LK Moore, S Schültke… - Developmental Cell, 2022 - cell.com
Excessive Na+ in soils inhibits plant growth. Here, we report that Na+ stress triggers primary
calcium signals specifically in a cell group within the root differentiation zone, thus forming a" …
calcium signals specifically in a cell group within the root differentiation zone, thus forming a" …
Advances in applying computer-aided drug design for neurodegenerative diseases
Neurodegenerative diseases (NDs) including Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …
Structural determinants and functional consequences of protein affinity for membrane rafts
Eukaryotic plasma membranes are compartmentalized into functional lateral domains,
including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …
including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …