Two decades ago successful transfection of antigen presenting cells (APC) in vivo was
demonstrated which resulted in the induction of primary adaptive immune responses. Due to …

Interest in bulk biomass from microalgae, for the extraction of high-value nutraceuticals, bio-
products, animal feed and as a source of renewable fuels, is high. Advantages of microalgal …

Recent human decedent model studies, and compassionate xenograft use have explored
the promise of porcine organs for human transplantation. To proceed to human studies, a …

Most general anaesthetics and classical benzodiazepine drugs act through positive
modulation of γ-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in …

Base editors enable targeted single-nucleotide conversions in genomic DNA. Here we show
that expression levels are a bottleneck in base-editing efficiency. We optimize cytidine (BE4) …

Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid
tumors is crucial for tumor clearance. We engineered CAR-T cells to express interleukin (IL) …

Exosomes are extracellular vesicles of endosomal origin that are released by practically all
cell types across metazoans. Exosomes are active vehicles of intercellular communication …

We report the engineering of mScarlet, a truly monomeric red fluorescent protein with record
brightness, quantum yield (70%) and fluorescence lifetime (3.9 ns). We developed mScarlet …

Cloning of multiple genes in a single vector has greatly facilitated both basic and
translational studies that require co-expression of multiple factors or multi-units of complex …

Atypical teratoid/rhabdoid tumors (ATRTs) typically arise in the central nervous system
(CNS) of children under 3 years of age. Despite intensive multimodal therapy (surgery …