T cells in health and disease

L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

Z Chen, A Bozec, A Ramming, G Schett - Nature Reviews …, 2019 - nature.com
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of
spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and …

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

N Tajik, M Frech, O Schulz, F Schälter, S Lucas… - Nature …, 2020 - nature.com
Gut microbial dysbiosis is associated with the development of autoimmune disease, but the
mechanisms by which microbial dysbiosis affects the transition from asymptomatic …

Pathogenic role of immune cells in rheumatoid arthritis: implications in clinical treatment and biomarker development

HY Yap, SZY Tee, MMT Wong, SK Chow, SC Peh… - Cells, 2018 - mdpi.com
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that
affects synovial joints, both small and large joints, in a symmetric pattern. This disorder …

Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells

S Rauber, M Luber, S Weber, L Maul, A Soare… - Nature medicine, 2017 - nature.com
Inflammatory diseases such as arthritis are chronic conditions that fail to resolve
spontaneously. While the cytokine and cellular pathways triggering arthritis are well defined …

Role of the IL-23/IL-17 axis in psoriasis and psoriatic arthritis: the clinical importance of its divergence in skin and joints

MA Boutet, A Nerviani, G Gallo Afflitto… - International journal of …, 2018 - mdpi.com
Psoriasis is a chronic systemic inflammatory disease causing erythematosus and scaly skin
plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is …

Migration and homeostasis of regulatory T cells in rheumatoid arthritis

K Kotschenreuther, S Yan, DM Kofler - Frontiers in Immunology, 2022 - frontiersin.org
Regulatory T (Treg) cells are garnering increased attention in research related to
autoimmune diseases, including rheumatoid arthritis (RA). They play an essential role in the …

Immunomodulatory role of T helper cells in rheumatoid arthritis: a comprehensive research review

P Luo, P Wang, J Xu, W Hou, P Xu, K Xu… - Bone & joint …, 2022 - boneandjoint.org.uk
Rheumatoid arthritis (RA) is an autoimmune disease that involves T and B cells and their
reciprocal immune interactions with proinflammatory cytokines. T cells, an essential part of …

Interleukin-9 facilitates osteoclastogenesis in rheumatoid arthritis

S Kar, R Gupta, R Malhotra, V Sharma… - International journal of …, 2021 - mdpi.com
In rheumatoid arthritis (RA), inflammatory cytokines play a pivotal role in triggering abnormal
osteoclastogenesis leading to articular destruction. Recent studies have demonstrated …

An update on interleukin-9: from its cellular source and signal transduction to its role in immunopathogenesis

S Chakraborty, KF Kubatzky, DK Mitra - International journal of molecular …, 2019 - mdpi.com
Interleukin-9 (IL-9) is a pleiotropic cytokine and was primarily studied in the context of T
helper 2 (TH2)-associated immuno-pathological conditions such as asthma and parasitic …