Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

RAS proteins are small GTPases known for their involvement in oncogenesis: around 25%
of human tumors present mutations in a member of this family. RAS operates in a complex …

Abstract The PI3K/Akt signal transduction cascade has been investigated extensively for its
roles in oncogenic transformation. Initial studies implicated both PI3K and Akt in prevention …

The tumor suppressor PTEN was originally identified as a negative regulator of the
phosphoinositide 3-kinase (PI3K) signaling, a main regulator of cell growth, metabolism and …

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important
pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells …

Abstract The Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-
signal-regulated kinase (ERK) cascade couples signals from cell surface receptors to …

Within the last 15 years, multiple new signal transduction pathways within cells have been
discovered. Many of these pathways belong to what is now termed 'the mitogen-activated …

Mutational activation of Ras promotes oncogenesis by disrupting a multitude of normal
cellular processes. Perhaps, best characterized and understood are the mechanisms by …

Abstract Dent, P., Yacoub, A., Contessa, J., Caron, R., Amorino, G., Valerie, K., Hagan, MP,
Grant, S. and Schmidt-Ullrich, R. Stress and Radiation-Induced Activation of Multiple …

We have recently shown that the Ras-Raf-MEK-ERK and phosphatidylinositol 3-kinase
(PI3K)-Akt signaling pathways can cross-talk in the human breast cancer cell line MCF-7 …