The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …

The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

Apoptosis may contribute to a significant proportion of neuron death following acute brain
ischemia (ABI), but the underlying mechanisms are still not fully understood. Brain ischemia …

Programmed cell death (PCD) or apoptosis is a mechanism which is crucial for all
multicellular organisms to control cell proliferation and maintain tissue homeostasis as well …

To date, over 100 small-molecule oncology drugs have been approved by the FDA.
Because of the inherent heterogeneity of tumors, these small molecules are often …

Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases
and blocks cell death, is highly expressed in most cancers and is associated with a poor …

Survivin is the smallest member of the inhibitor of apoptosis protein family, which has key
roles in regulating cell division and inhibiting apoptosis by blocking caspase activation …

Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function
(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal …

Acquisition of the ability to evade cellular suicide, or apoptosis, is one of the master switches
that contributes to cellular transformation and, ultimately, to invasive cancer. Much has been …

Survivin, a member of the family of inhibitor of apoptosis proteins, functions as a key
regulator of mitosis and programmed cell death. Initially, survivin was described as an …