Intrahepatic islet transplantation is a promising β-cell replacement strategy for the treatment
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …

The effective suppression of adaptive immune responses is essential for the success of
allogeneic cell therapies. In islet transplantation for Type 1 Diabetes, pre-existing …

Type 1 diabetes mellitus (T1DM) results from an autoimmune attack against the insulin-
producing ß cells which leads to chronic hyperglycemia. Exosomes are lipid vesicles …

A major obstacle in the survival and efficacy of tissue engineered transplants is inadequate
oxygenation, whereby unsupportive oxygen tensions result in significant cellular dysfunction …

The detailed characterization and quantification of the kinetics of glucose-stimulated insulin
secretion (GSIS) by normal pancreatic islets is of considerable interest for characterizing β …

To explore the effects immune‐isolating encapsulation has on the insulin secretion of
pancreatic islets and to improve our ability to quantitatively describe the glucose‐stimulated …

Transplant of hydrogel-encapsulated allogeneic islets has been explored to reduce or
eliminate the need for chronic systemic immunosuppression by creating a physical barrier …

We report the design and fabrication of a robust fluidic platform built out of inert plastic
materials and micromachined features that promote optimized convective fluid transport. The …

Islet transplantation is a promising therapy for Type 1 diabetes mellitus; however, host
inflammatory and immune responses lead to islet dysfunction and destruction, despite …

The transplantation of human pancreatic islets is a therapeutic possibility for a subset of type
1 diabetic patients who experience severe hypoglycemia. Pre-and post-transplantation loss …